الفهرس 
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Abstract
AIM: To investigate the association between the single nucleotide polymorphisms(SNPs) in -88 and -123 loci of myxovirus resistance-1 (MxA) gene promoter region and the treatment response to IFN-α.
METHODS: Genotypes of -88(G/T) and -123(C/A) loci of the MxA promoter region were examined by the polymerase chain reaction in hundred Egyptian patients with chronic hepatitis Cand sixty healthy controls.
RESULTS:The T-alleles of MxA-88 locus and the A-alleles of MxA-123 locus may be associated with the response to interferon.The frequency of the G/TandC/Agenotypeswas significantly higher in the responder group of patients (63.50% and 49.20%respectively) than in the non-responder group (21.60% and 29.70%respectively)
CONCLUSION: The results of the current work implied that heterozygosity for both the –88 and –123 polymorphisms of the MxA gene may be important host factors that influence the response to IFN-α therapy in patients with chronic HCV infection.