الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 16 |  |  |
| | | from | 16 | | |
Abstract
Lichen planus is T-cell-mediated chronic inflammatory skin disease characterized by an itchy, polygonal flat -topped pink or purple papules. The exact causes of LP are not known. Cardiovascular risk factors; including hypertension, diabetes, obesity, metabolic syndrome and dyslipidemia have been assessed with LP. Atherogenic lipid profile leads to atherosclerosis which may be complicated by cerebral stroke, myocardial infarction or peripheral vascular disease. Also hypertriglycridemia is associated with CV diseases which are one of the principle causes of morbidity and mortality. Thus, we aimed in the present study to investigate the association between LP and dyslipidaemia to detect individuals at risk of CV disease. This study was conducted on 40 patients attending to Dermatology Clinic, Ashmone Hospital within the period between January 2014 and March 2015. Twenty age , sex and BMI matched healthy subjects were served as controls.
All individuals in the study were subjected to history taking, clinical examination including calculation of BMI, Dermatological examination to determine type, distribution and extension of LP lesions,and biochemical measurment of serum levels of total Cholesterol, HDL- Cholesterol, LDL – Cholesterol, and triglycerides.
The presence of dyslipidaemia was defined if one of the following parameters were present: triglycerides >150 mg ⁄ dL, total cholesterol >200 mg⁄ dL, LDL-C >130 mg⁄ dL. Then Atherogenic index of plasma (AIP); log (TG/HDL-C) was calculated.
In the present study, both LP patients and controls were matched regarding age, sex and BMI. Dyslipidemia was diagnosed in 47.5% of patients versus none of the controls with highly significant difference between both. However, there was a non significant difference between dyslipidemic and non dyslipidemic patients as regards to age, gender and disease duration.
Regarding lipid profile, patients with LP had significantly higher serum cholesterol, and LDL than those of the controls. Also, they tended to have higher TG mean values than controls (p=0.07), however, no difference have been detected between patients and controls regarding serum HDL levels. Females with LP had significantly lower cholesterol and higher HDL serum levels than males. Despite the non significant differences between LP patients and controls regarding TG and HDL serum levels, there was a highly significant difference between both as regards to atherogenic index However, no statistically significant difference between both gender regarding AIP had been detected.
In the present study, there was a highly significant positive correlation between AIP and age of patients. Also, there was a tendency of high risk patients to be of older age.
In addition, no significant correlation has been detected between AIP and duration of LP. Also atherogenic index categories were not associated with either patient gender or disease duration.