الفهرس 
Introduction and review of literatures.Only 14 pages are availabe for public view
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Abstract
Colorectal carcinoma (CRC) is one of the most common neoplasms affecting individuals in most western countries. Colorectal cancer is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the US (American cancer society, 2014). CRC was the 6th cancer in Egypt, representing 4% of the total cancers and 53% of GIT cancers. The median age was 53 years with male predominance. Colon cancers were more common than rectal cancers (Zeeneldin et al., 2012).
There are several risk factors which involved in pathogenesis of colorectal cancer such as personal history of colorectal cancer, environmental factors (diet, obesity, diabetes mellitus, alcohol, smoking, pesticides, physical activity), older age and Schistomiasis (Stewart and Kleihuse, 2003).
ERM (ezrin / radixin / moesin) family of proteins is involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures (Brestscher et al, 1997 and Mangeat et al., 1994). ERM linkers concentrate in cell surface structures rich in actin such as microvilli and filopodia, and their impaired expression or inactivation severely alters cell surface morphology, motility, and adhesion ( Brestscher et al., 2000 ).
Summary
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Ezrin acts as link between the cell membrane and actin cytoskeleton to integrate cell adhesion-mediated signaling. It implicates tumor progression, metastatic dissemination, and adverse outcomes in several cancer types, including pediatric and adult sarcomas (Wei et al., 2009). Little is known about the role of ezrin and moesin in colorectal cancer. Moesin protein is implicated in various tumors, in oral squamous cell carcinoma (Kobayashi et al., 2004, papillary thyroid carcinomas (Brown et al., 2006) and glioma cell growth (Zhu et al., 2012).
This study aimed to evaluate the percentage and patterns of ezrin and moesin expressions in colorectal carcinoma together with correlating their expressions with the clinicopathologic features of the neoplasm.
This study was carried out on fifty eight colorectal specimens from Egyptian patients retrieved from Pathology Department, Faculty of medicine, Menofiya University in the period between May 2007 and May 2011. They were randomly selected, based on the availability of paraffin-embedded blocks for serial cutting and examination.
The studied cases included: 10 colorectal adenoma and 48 colorectal carcinoma. All studied adenoma cases were endoscopically resected mucosa or endoscopically resected polyps, however, all the studied carcinoma cases were surgically resected colectomy specimens.
Summary