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Abstract 2-Alkylmercapto-4-oxo-6-phenyl-3,4-dihydropyrimidine-5-carbonitrile derivatives IIa-c synthesized by reaction of 4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile Iwith alkyl halides. Reaction of pyrimidine derivativesIIa-c with phosphorus oxychloride give 2-alkylmercapto-4-chloro-6-phenyl-3,4-dihydropyrimidine-5-carbonitrilesIIIa-c. Compounds IIIa-cconverted into 2-alkylmercapto-4-mercapto-6-phenylpyrimidine-5-carbonitrilesIVa-cvia reaction with thiourea in refluxed ethanol(Scheme 1). |