الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Cancer is a group of diseases that cause cells in the body to change and grow out of control. Most types of cancer cells even¬tually form a lump or mass called a tumor, and are named after the part of the body where the tumor originates.
The high prevalence of breast cancer and the limited options for treatment provide a strong rationale for identifying new molecular targets that can be nutritionally or pharmacologically modulated and offer a potential for chemoprevention. Among the regulatory molecules that have been characterized as holding great promise for breast cancer treatment is cyclooxygenase-2 (Cox-2)
Cyclooxygenases also known as prostaglandin endoperoxide H synthases or prostaglandin G/H synthases) are key enzymes in mediating the conversion of free archidonic acid into prostaglandin H2. These active products are important regulators of many biologic processes such as inflammation, immune function, cell proliferation, and angiogenesis, which are all relevant to cancer development and progression).
Selenium (Se) is well known as an essential trace mineral and an essential cofactor for glutathione peroxidases (GPx), selenoprotein P, and thioredoxin reductase, which are involved in scavenging free radicals and maintaining the redox balance.
In a study conducted by the International Breast Cancer Study Group (IBCSG), ALP was examined for their sensitivity in detecting breast cancer recurrence. ALP alone was abnormal in a high proportion of breast cancer patients with bone metastases and/or liver metastases.