الفهرس 
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Abstract
This study was conducted on 25 patientswith anincidentally discovered diffuse fatty liver by US. There where twenty five asymptomatic patients (10 were men, and 15 were women). The overall mean age was 51.6 ± 11.1years (range, 30 – 66 years).
The aim of this work is to study the role of IPOP magnetic resonance imaging in quantification of liver fat content in patients with NAFLD.
All Patients in this study were subjected to thorough history takingincluding age, sex and medical history, full clinical examination including vital signs, general examination, measurements of weight, standing height andBMI, real time abdominal US, US-guided ‘Tru-Cut’ needle biopsy of the liver, in-phase and out-of-phase MR imaging, histopathological examination of liver biopsy specimens.
NAFLD is slightly more common in postmenopausal women. The possibility that female hormones protect against NAFLD has been postulated and supported by evidence that NAFLD is twice as common in postmenopausal women as in premenopausal women. Those who receive hormone replacement therapy are significantly less likely to have NAFLD compared with women who do not.
Hepatic steatosis may be influenced by visceral fat accumulation regardless of body mass index. Visceral fat accumulation appears to be a significant risk for the development of NAFLD.
In-phase and out-of-phase MR images provide useful information about the LFC that is consistent with liver biopsy results. Our findings show that a simple method can be used to determine if LFC is within the normal range. Measurements from in-phase and out-of phase images provides a more reliable approximation of the true LFC than does subjective image interpretation, even if the interpretation is performed by an experienced radiologist. The advantages of this method are that it can be a guideline for less experienced radiologists and it is valid throughout the wide range of LFCs often observed in patients with type 2 diabetes mellitus and NAFLD.
The IPOP MRI showed high sensitivity and specificity in detecting steatosis,regardless of whether using equation FI1 or FI2 to estimate LFC.
As a clinical rule of thumb, a cutoff value of 5.1% was chosen to allow rapid discrimination between normal and increased LFC based on IP-OP imaging data alone. Increased use of IP-OP imaging to assess LFC has the potential to promote early detection of NAFLD and to potentially improve treatment evaluation.