الفهرس 
Introductionيوجد فقط 14 صفحة متاحة للعرض العام
 |  | from | 32 |  |  |
| | | from | 32 | | |
المستخلص
The histo and clinicopathological effect of MSG (food enhancer) and SMB (food preservatives) on different tissues and organs of male Albino rats were investigated. Eighty male Albino rats (150-180 gm) were divided into 5 groups administrated 30 and 60 mg/kg b.wt of MSG; 260 and 520 mg/kg b.wt of SMB for 12 weeks per oss and control group. Treated rats were sacrificed at 2, 4،8 and 12 weeks from beginning the experiment.Our results revealed tat MSG by a dose of 30 mg/kg b.wt showed significant decrease in Hb concentration, PCV, MCV and MCH at 2 weeks, MCH at 4 weeks post administration. Significant increase in leukogram, platelet counts, GOT, BUN and creatinine values at 4 weeks, total leukocytic counts and BUN values at 8 weeks and Hb concentration, total protein, BUN and creatinine values at 12 weeks post administration. Rats treated with MSG at dose 60 mg/kg b.wt showed significant increase in the number of RBCs, GPT, GOT and BUN values at 2 weeks, Leukogram, platelet counts, GOT, BUN values at 4 weeks, BUN and creatinine values at 8 weeks and Hb concentration, MCHC, GOT, BUN and creatinine values at 12 weeks post administration.Our results revealed that MSG by a dose of 30 mg/kg b.wt and 60 mg/kg b.wt showed mild to severe adverse effect on the body organs included congestion in liver, lung, testes, brain and kidney with the presence of grayish white foci on cutting surface of liver and kidney, atrophy of the testes and heart showed presence of petechial and grayish streaks on the heart surfaces.
Our results revealed that MSG by a dose of 30 mg/kg b.wt microscopically, the liver showed congestion of blood vessels with perivascular leukocytic infiltration and degenerative changes in hepatocytes. Lung showed mildest degree of hyperplasia of the epithelial lining of the bronchioles with the presence of eosinophilic debris in the bronchial lumina and peribronchial leukocytic infiltrations. Testes showed mild congestion of the testicular blood vessels with mild intertubular edema, degenerative changes and necrosis of the epithelial cell lining of the seminiferous tubules. Brain showed congestion of meningeal and brain blood vessels with focal small area of malacia. Kidney showed mild congestion of the renal blood vessels and intertubular blood capillaries and the renal tubules showed mild degenerative changes with presence of eosinophilic debris in their Lumina. Stomach showed leukocytic infiltration in the lamina propria and mild degenerative changes in the glandular epithelium. Also affect intestine showed mild degenerative changes in the epithelial lining of the intestinal villi with leukocytic infiltration in the lamina propria. Heart showed small focal areas of hyalinosis in the cardiac muscle and focal areas of intermuscular hemorrhage.