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العنوان
Surgical management of liver tumors in pediatric age group: Longtudinal study at National Liver Institute /
المؤلف
Ibrahim, Mamdouh Ahmed.
هيئة الاعداد
باحث / Mamdouh Ahmed Ibrahim
مشرف / Khaled Ali Abou El-ella
مشرف / Tarek Mohamed Ibrahim
مناقش / Hesham Mohamed Abdeldayem
الموضوع
Cancer in adolescence. Neoplasms. Adolescent.
تاريخ النشر
2015.
عدد الصفحات
193 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الكبد
تاريخ الإجازة
9/8/2015
مكان الإجازة
جامعة المنوفية - معهد الكبد - جراحة الكبد
الفهرس
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Abstract

This study was done to evaluate the outcome of surgical management of pediatric liver tumors in the period from 2000- 2012 in the department of surgery National Liver Institute menoufiya Univeristy a retrospective and prospective study. There were 36 patients; 27 patients (75%) retrospective and 9 patients (25%) prospective. There were 21 male patients (58.3%) and 15 female patients (41.6%), the age ranged between o.3-18 years. There were 20 patients (55.6%) had benign tumors and 16 patients (44.4%) had malignant tumors. The most common benign pediatric liver tumors was hemangioma 13 patients (65%), mesechymal hamartoma3 patients (15%), focal nodular hyperplasia 2 patients (10%), liver adenoma one patient (5%) and infantile hemangioendothelioma one patient (5%). There were 16 patients (44.4%) had malignant tumors, 12 patients of them (75%) hepatoblastoma and 4 patients (25%) hepatocelullar carcinoma. The most common presentation were abdominal mass(100%) some cases discovered incidetaly or at laboratory examination, the diagnosis was established by (US, CT, MRI) and increase alpha fetoprotein. The treatment of benign liver tumors 19 cases (95%) was surgically resected and one case (5%) infatil hepatic hemangioendothlioma underwent transplantation.
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Treatment of malignant liver tumors (16 cases), 12 cases (75%) hepatoblastoma 4 cases (25%) hepatocellarcarcinoma. We use neoadjuvant chemotherapy to dowenstaging the tumors so we had 2 cases downstage from stage III to stage II after chemotherapy. In hepatoblastoma we had 11 cases (91.9) surgically resected, one case (8.3%) transplanted, but the 4 case (100%) hepatocellularcarcinoma underwent rsection. There were some complication as bile leak, bile fistula and hemorrhage, there no mortality in benign liver tumors and there was one case of hepatoblastoma died postoperative in the second surgical intervention 10 days after operation due to sever sepsis and another case hepatocellularcarcinoma died 2weeks after second surgical intervention due to liver failure. Follow up of malignant liver tumors after one year about 90% , after 3 years about 70% and after 5 years about 50%.