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Abstract Color Duplex Doppler sonography provides not only morphologic but also physiologic data when studying renal blood flow, as well as explore renal vessels in various disease including (renal obstruction, renovascular hypertension, acute or chronic renal failure, or diabetic renal complication) by measuring the RI of renal parenchymal arteries in each kidney. So we can summarize that the Color Duplex U/S provides very useful information, the intrarenal resistance index (R.I) is used as a predictor in patients with diabetic nephropathy by assessment of alterations in vascular perfusion showing general perfusion in color. We therefore, concluded that in renal parenchymal disease, measuring RI by Doppler ultrasonography is a fair predictor of renal function and documented early intrarenal hemodynamic alterations in the form of pathologically elevated intrarenal RI. This denotes the potential usefulness of duplex evaluation of the intrarenal arteries, as a noninvasive procedure, for monitoring diabetic patients and predicts those at risk of diabetic nephropathy. In summary for the results of this study, the clinico-laboratory parameters (blood sugar level, and serum creatinine) were shown to have a positive correlation, and a statistically significant co-variables influencing R.I, except for the diabetic duration which gives a weak correlation and not reaching a statistically significant values. The blood pressure in this study is not included as a statistically significant correlates, because all patients were normotensive and under treatment. Finally we can conclude that in renal parenchymal disease, measuring RI by Doppler ultrasonography is a fair predictor of renal function, where interarenal RI value of ≥ 0.70 identifies diabetic patient at risk of progressive renal disease, as RI seems to be dependable marker of intrarenal changes and can be used as a non-invasive, easily available parameter of the evolution in patients with advanced clinical diabetic nephropathy. |