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Abstract The aim of the present investigation was to study the effect of Nicorandil used separately or coupled with Propolis on the gingiva, periodontal ligament and alveolar bone of the rat through: Microscopic examination of the above mentioned structures using Haematoxylin and Eosin and Masson’s trichrome stains to detect any possible histopathological findings. Immunohistochemical localization of Interleukin 1 beta and transforming growth factor beta 2 in the aforementioned structures. |