الفهرس 
HemophiliaOnly 14 pages are availabe for public view
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Abstract
In this work we aimed to:
To asses bone mineral density in severe and moderate
haemophilia a patient using osteoprotogrin level and
DEXA scan.
The present study was conducted on 35 haemophilic
patient were recruited from Haematology Clinic, Children
Hospital, Ain Shams University. All patients were males
and 15, age matched normal subjects were included as
control group, A verbal consent was obtained from patients
or their parents or legal guardians before enrollment in the
study.
All patients included in this study were subjected to:
1. Complete history taking stressing on the following:
Age
Sex
Severity
History of hemarthrosis or history of any joint
affection.
Factor VIII level.
2. Clinical examination include
Complete joint examination
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3. Anthropometric measurement
4. Investigation
Include
1. Prothrombin Time (PT), Partial Thromboplastin Time
(PTT) and Factor VIII Assay.
2. Serum osteoprotogerin.
3. Dual energy x-ray absorptiometry (DEXA) scans to
asses whole body BMD.
The study showed that
1. The mean value of Opg in Moderate cases was
11.557±6.541.
2. The mean value of Opg in Sever cases 11.764±4.902.
3. The mean value of BMD total in Sever cases was
0.877±0.058
4. The mean value of BMD total in Moderate cases was
0.826±0.092
5. The mean value of BMD z-score in Moderate cases was
1.112±1.087
6. The mean value of BMD z-score in Sever cases was
0.914±0.85.
7. There was non significant difference between case
group and control group regarding age
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8. There were non significant difference between cases
with moderate or severe forms regarding age, weight,
height or BMI.
9. There was non significant difference between moderate
and severe cases regarding affected joints.
10. There were non significant difference between
moderate and severe cases regarding all clinical
manifestations including axial deformity, muscle
atrophy, redness, stiffness, joint swelling and limited
movements.
11. There was highly significant lower OPG level in case
group compared control group.
12. There was non significant difference between cases
with moderate or severe forms regarding OPG
13. There were non significant difference between cases
with moderate or severe forms regarding BMD total
and z-score.
14. There were non significant correlation between OPG
and all parameters (age, weight, height, BMI and BMD)
in moderate cases.
15. There was significant positive correlation between
BMD total with age, weight and height.
16. There was significant positive correlation between
BMD z-score and age.
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17. There was non significant correlation between OPG and
BMD z-score with all parameters (age, weight, height,
BMI and BMD) in severe cases.
18. There was significant positive correlation between
BMD total with age, weight and height.