الفهرس 
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Abstract
The work in this thesis is focused on the preparation and characterization employing elemental analyses, thermal (TG and DTG), spectral (IR, UV-Visible, 1H NMR and 13C NMR) and magnetic measurements of new complexes of N’1,N’2-bis((E)-1-(pyridin-2-yl) ethylidene)oxalohydrazide and 2-phenyl-N’1,N’3-bis((E)-1-(pyridin-2-yl)ethylidene) malonohydrazide with Mn(II), Co(II), Ni(II), Cu(II) ,Cr(III), Fe(III), Cd(II), Zn(II), Hg(II) and U(VI)O2 metal ions. The biological activity was carried out Chapter one displays different publications concerning the complexation of hydrazones with a great attention to the compounds similar to that investigated and their biological activities. The second chapter covers the experimental part and illustrates the experiments used in this work. It includes list of reagents, stock solutions along with the physical measurements and instrumentation. The working procedures were also discussed as well as a description for the preparation of the ligands and its metal complexes. In addition, this chapter includes the recommended procedures for the antitumor activity of prepared metal complexes. Chapter three deals with the results and discussion which are summarized to give the following information: The proposed chemical formulae of the ligands and their metal complexes are in good agreement with the stoichiometries concluded from their analytical data of carbon, hydrogen, nitrogen and metal contents. Most of complexes have high melting points (>300˚C) and insoluble in most organic solvents. The coordination sites of the ligand, the nature of metal-ligand bonds and the existence of the solvated molecules have been elucidated using IR spectra. Different modes of chelation for the investigated ligands are suggested based on careful comparison between the spectra of the ligands and their corresponding complexes. The 1H NMR spectra of the diamagnetic Cd(II), Hg(II) and Zn(II) complexes are used to detect the potential coordination sites. Detailed thermal analysis for the prepared complexes was performed in the temperature range 30-700 or 800˚C. The thermograms show the decomposition steps after which a constant weight is observed corresponding to the remaining part of the complex. The geometries are suggested for the prepared complexes based on the data evaluated from spectral and magnetic measurements. The final part in this chapter deals with the antibacterial activity and the antitumor activity for H2OHS and H2OAP and their metal complexes.