الفهرس 
Abstract
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Abstract
The present study aims to evaluate the possible ameliorative effect of moringa extract and vitamin E alon or their combination against zinc oxide nanoparticles- induced liver toxicity in male albino rats. 90 Male Wistar albino rats were divided into nine groups (n = 10). The 1st (normal control group) received distilled water. The 2nd (control group) in which rats received twin 80. The 3rd (moringa extract treated group) rats were treated orally with aqueous suspension of moringa extract in a dose of (150 mg/kg. bw) daily for successive (30 days) using metallic stomach tube, The 4th (vitamin E treated group), rats were treated orally with vitamin E at a dose of (100mg/kg. bw). The 5th (3rd ZnO nanao treated group) for 30 days, received rats were orally administered with aqueous suspension ZnO nanoparticles in adose of (7.5 mg/kg. bw) daily for successive 15 day. The 6th ( (ZnO nanao plus moringa extract treated group), Rats were orally administered with aqueous suspension ZnO nanoparticles in a dose of (7.5 mg/kg. bw) daily for successive 15 days then administered with aqueous moringa extract in adoes of (150 mg/kg. bw) daily for successive 30 days.
The 7th (ZnO nanao + vitamin E treated group), Rats were orally administered with aqueous suspension ZnO nanoparticles in a dose of (7.5mg/kg. bw) daily for successive 15 days then administered with vitamin E in adoes of (100mg/kg. bw) daily for successive 30 days .The 8th (ZnO nanao + moringa extract & vitamin E treated group treated group), Rats were orally adminstersd with ZnO nanoparticles for 15 days then treated with aqueous suspension of moringa extract and vitamin E daily for successive 30 days and The 9th (ZnO nanao + silymarint reated group) Rats were orally adminstersd for zno nanoparticles in adose of (7.5mg\kg) for 15 days then treated with silymarin for 30 days. After 45 day, blood and specimens were collected., ALT, AST, ALP, GGT total protein, total bilirubin, direct bilirubin, albumin, bilirubin, direct bilirubin, creatinine, urea, uric acid, BUN, cholesterol, triglycerides, total lipid and some antioxidants assay (SOD, CAT, GST and GSH) were investigated In addition MDA. The results showed that administration of ZnO NPs caused an undesirable effect on most of studied biochemical parameter. The moringa and vitamin E administration for 30 days subsequent to ZnO NPs exposure afforded significant ameliorative effects on nearly all studied parameters, and such effect were found compatible with the effect caused by silymarin as hepatoprotective drug.
Keywords: nanoparticles, Oxidative stress, zinc oxide , vitamin E, Hepatotoxicity