الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
This study was carried out in El-Minia University Hospital in the period from April to October 2014 on Nintey patients ASA physical state I & II, aged between 1-10 years undergoing orthopedic surgery. Those patients were randomly devided into three equal groups each included 30 patiens;
Group K: received ketofol (ketamine 0.25mg/kg and propofol 1.0 mg/kg in combination diluted to a volume of 10ml saline by addition of normal saline) 10 minutes before end of surgery.
Group D: received dexmedetomidine (0.3mic/kg diluted in normal saline10ml) 10 minutes before end of surgery.
Group C: received normal saline (10ml) 10 minutes before end of surgery(placebo group).
We aimed in this study to test the effect of dexmedtomidine and ketofol on the incidence of emergence agitation during sevoflurane anesthesia in children.
Induction of anesthesia was done by 8% sevoflurane with 100% oxygen which was mentained at 8% till laryngoscopy, during that an intravenous line was established. Following the intravenous access, atropine 0.01 mg/kg, cisatracurium 0.15 mg/kg were given intravenously to the children in all groups.
All patients were assessed as regard the heart rate, mean arterial blood pressure and O2 saturation preoperatively and intraoperatively every 10 minutes till the end of surgery.The level of agitation was recorded using the AONO’S score for Emergence Agitation at t0, t10, t20 and t30 minutes. Also the duration of recovery stay were recorded.
Our results showed that there was insignificant statistical difference between the three groups as regard the demographic data (age, sex and weight) and duration of surgery.
Also the results showed that ketofol as effective as dexmedetomidine in reducing the incidence of emergence agitation.
In the contrast, ketofol is better than dexmedetomidine in the 1st analgesic requirement, time to extubate and time to gain consciousness.
But, dexmedetomidine better hemodynamic stability than ketofol.