الفهرس 
? Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
The involvement of the opioid system in energy balance has been known for several decades but many questions remain unanswered. Therefore, this study was designed to investigate the effect of the non-selective opioid receptor agonist (Tramadol) and antagonist (LY255582) on high fat diet (HFD) induced obesity. Consumption of HFD resulted in a significant increase in body weight, BMI, glucose, insulin, leptin levels and induced a state of dyslipideamia. Opioid antagonist administration with HFD decreased food intake, body weight and BMI, in addition to the improvement of HFD related metabolic abnormalities during the dynamic phase of obesity development than in animals with preexisting dietary obesity. On the other hand, treatment with the opioid agonist caused marked decrease in food intake, body weight, and BMI, but with no significant effect on the HFD induced metabolic disorders. Conclusion, the use of opioid antagonist may be a promising approach in treatment of HFD-induced obesity.