الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 32 |  |  |
| | | from | 32 | | |
Abstract
The present study included 40 non diabetic patients with different stages of CKD group I and 20 healthy controls group II. The mean age in group I 40.9±11.47 years while in group II 36.3±11.88 years, the control group was matched as regard age and sex to the patient group.
All subjects in the study had, in addition to routine investigations, measurement of serum electrolytes, ABG, calculation of AG and measurement of serum osmolality by freezing point depression and also determination of SSR using electrical stimulation applied to upper extremities.
In group I, mean serum creatinine was 3.44±1.82 mg/dl while in group II was 0.77±0.19 mg/dl . A statistically significant difference was found between the two studied groups.
Mean RBS, blood urea, serum Na+, calculated osmolality, measured osmolality and OG in group I were 92.25±19.02 mg/dl, 88.23±43.75 mg/dl, 134.0±5.21 mEq/L, 287.83±15.67 mOsm/kg, 301.95±20.51 mOsm/kg and 22.24±21.53 mOsm/kg respectively. While in group II were 84.65±11.99 mg/dl, 34.0±8.57 mg/dl, 137.7±4.5 mEq/L, 285.76±9.01 mOsm/kg, 302.2±5.15 mOsm/kg and 16.69±10.11 mOsm/kg respectively.
There was significantly lower serum Na+ and higher blood urea levels in patients group when compared to controls with no statistically significant difference as regards the other mentioned variables.
The mean values for serum Cl-, serum HCO3- and AG in group I were 101.02±4.5 mEq/L, 16.03±3.55 mEq/L, 16.94±7.77 mEq/L respectively, while in group II were 99.0±4.08 mEq/L, 24.55±2.09 mEq/L and 14.15±4.58 mEq/L respectively. Except for serum HCO3- there was no statistically significant difference found between the two groups.
The mean value for OG and AG in HD group were 28.84±16.70 mOsm/kg and 18.94 ± 5.24 mEq/L respectively, while those with predialysis CKD group were 20.81±22.39mOsm/kg and 16.52±8.20 mEq/L respectively, with no statistically significant difference in comparing the two subgroups as regard the previously mentioned variables.
The mean value of SSR regard latency and amplitude in group I were 1.67±1.36 sec and 45. 97±29.81 mV respectively. In the group II there were 1.47±0.28 sec and 35.5±13.87 mV respectively. There was statistically significant difference between the two groups.
The mean value for SSR regarding latency and amplitude in the two subgroups HD and predialysis CKD were 2.37±1.47 sec and 16.82 ±16.67 mV in HD group, while those for predialysis CKD were 1.52±1.31 sec and 52.34±28.73 mV respectively.
Predialysis patients with CKD have exaggerated SSR regarding the amplitude when compared to HD group.
No significant relation was found between the different stages of CKD or AG nor serum osmolality and OG.