الفهرس 
General IntroductionOnly 14 pages are availabe for public view
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Abstract
Sustained release oral liquids possess several advantages compared to sustained release solid dosage forms. Solid dosage form is formulated in different strengths to suit various treatment requirements while sustained release oral liquid dosage forms is formulated in one strength and various doses can be obtained by adjusting the quantity administered. They also decrease plasma level fluctuations and are more flexible in dose adjustment as opposed to conventional solid dosage forms where dividing the dose is not guaranteed to give an accurate dosing of the drug. Sustained release liquid dosage forms are more desirable for pediatrics and geriatrics& patients who are unable to tolerate solid dosage forms due to difficulty in swallowing. Furthermore, they are suitable for delivering drugs with a short biological half life where the dosing frequency is reduced. Therefore, patient compliance is significantly improved.
This study aimed at formulating and evaluating sustained release oral liquid dosage forms. Two different approaches have been adopted; insitu gel formation in response to change in pH which floated over the gastric fluid and loading a drug onto inert pellets which are further coated by a rate controlling layer.
This thesis is divided into two parts:
Part one: Sodium Alginate based Floating insitu Gelling System of Ibuprofen for Oral Sustained Delivery:
Floating oral in situ gelling liquid suspension compromising ibuprofen and sodium alginate (SA) was prepared in different ibuprofen SA ratios (F1;1:1, F2; 1:1.5, F3;2:1, F4;2:1.5 & F5;2:2, respectively). characterization of the sol and gel forms was carried out. DSC and FTIR studies were conducted to investigate the compatability of both ibuprofen and sodium alginate. In vitro release studies were conducted in a manner suiting the floating nature of the formulation where a modified Rosset-Rice dissolution test was selected taking into consideration the gastric acid secretion rate. Since the gel formed in situ remained floating for prolonged periods of time, evaluation of the ulcerogenicity and stomach protective activity of the selected formulation was necessary. Furthermore, in situ gelling liquid suspensions were exposed to accelerated stability testing under stress conditions (40°C&75%RH). Effect of ageing on the dissolution rate of the selected formulation was assessed.