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Abstract IR has a role in pathogenesis of atherosclerotic cardiovascular disease so has an important role in increase mortality rate in patient with ESRD. Several studies suggest an important role for IR in metabolic syndrome. However, the effect of HD on IR needs to be better defined. The aim of the present study was to explore the effect of HD session on IR and comparing this in diabetic and non-diabetic subjects with ESRD. The present study included 100 subjects with ESRD on chronic HD The main findings of the present study were: • Both diabetic and non diabetic patient with ESRD on chronic HD have a high level of IR. • There was a statistically significant correlation between IR and serum creatinine. • There was a statistically significant correlation between IR and the FPG. • There was a statistically significant direct correlation between IR and fasting serum insulin. • IR was significantly higher in the diabetic subjects in comparison to the non diabetic subjects. • There was a statistically significant improvement in FPG after HD session. • There was a statistically significant improvement in fasting serum insulin after HD session. • There was a statistically significant improvement in HOMA IR and delta HOMA after HD session. • There was a statistically significant difference between diabetic subjects and non diabetic subjects regarding following parameter; serum creatinine, FPG, fasting serum insulin, HOMA IR, duration of HD. |