الفهرس 
Acknowledgment.Only 14 pages are availabe for public view
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Abstract
This study was conducted as a cross-sectional study to assess the frequency of parvovirus B19 infection among children with chronic hemolytic anemia compared with healthy children, to determine the correlation between parvovirus B19 infection and severity of anemia and to determine the risk factors associated with parvovirus B19 infection among those children. This study was carried out at Pediatrics Department and Hematology Unit of Clinical Pathology Department, Suez Canal University Hospital. Fifty patients within study group (anemic group) and 50 volunteers (control group) matching age and sex of the study group were included.
The frequency of male patients was 56% in the control group and they were 48% in the hemolytic group, while the frequency of female patients was 44% in the control group and they were 52% in the hemolytic group. There was non significant difference between both groups regarding their sex (p>0.05). The weights, height, BMI of thalassemic patients were significantly less than control group (p<0.05).
There was significantly lower mean hemoglobin and higher mean of reticulocytic count in hemolytic group than in control group (6.51 ± 0.86 mg/dl and 9.06 ± 4.24 % versus 11.46 ± 1.38 mg/dl and 0.92 ± 0.34 %, respectively) (p<0.001).
The risk of Parvovirus B19 infection as detected by Parvovirus B19 IgM and IgG antibodies in hemolytic patients was not significantly higher than in normal population.
There were significantly higher frequencies of severe anemia in hemolytic group than in control group (96% versus 0%, respectively) (p<0.001).
There were non-significant differences between the severity of anemia according to the frequency of Parvovirus B19 IgM antibodies (p>0.05). There were non significant differences between the severity of anemia according to the frequency of Parvovirus B19 IgG antibodies (p>0.05).
The risk of severe hemolytic anemia was non- significantly higher in patients with positive IgM and IgG antibodies of Parvovirus B19.