الفهرس 
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Abstract
Diabetes mellitus (DM) is one of the most prevalent and serious chronic health conditions, can lead to a multitude of complications such as heart disease, stroke, renal failure, amputation and blindness. Diabetes, when uncontrolled, causes dyslipidemia often followed by atherogenic abnormalities. It is caused by defects in insulin mediated signal pathways, resulting in decreased glucose transportation from blood into muscle and fat cells. The present study was aimed to determine the effect of agarics bisporus powder (ABP), ferulic acid (FA), pomegranate molasses (PM) as a potential natural therapeutic agents compared to chromium picolinate (Cr.Pic) against diabetes induced by streptozotocin (STZ) accompanied with hyperlipidemia in male rats. One hundred and four waster male rats divided into 13 equal groups, each of 8 rats. Diabetes was induced by streptozotocin and treated for 21 days. Blood samples and pancreatic tissue were collected at 22th day from the treatment. The obtained results showed that, STZ-induced diabetes showed a significant increase in glucose concentration with significant decrease in insulin level and glucose-6-phosphate (G6PD) activity. While, showed significant increase in cholesterol, triglyceride, low-density lipoprotein (LDL) and significant decrease in (high-density lipoprotein) HDL levels. Also showed significant increase in malondialdehyde (MDA) level and significant decrease in catalase (CAT), glutathione peroxides (GPx), superoxide dismutase (SOD) activities and glutathione (GSH) level. Liver enzyms alanine aminotransferase (ALT), aspartate aminotransferase (AST) were significantly increased compared with control group. Urea and creatinine (Kidney function) levels showed no significant changes. Animal’s body weight was significantly decreased through experimental period compared with control group. Histological studies of pancreatic tissue showed atrophy in island of Langerhans cells. Results showed that diabetic rats induced by STZ and treated with ABP or FA or PM or Cr.Pic showed a significant decrease in glucose concentration with significant increase in insulin level and glucose-6-phosphate (G6PD) activity. Also, showed significant decrease in cholesterol, triglyceride, low-density lipoprotein (LDL) and significant increase in high-density lipoprotein (HDL) levels. Malondialdehyde (MDA) level was significantly decreased and significant increase in catalase (CAT), glutathione peroxides (GPx), superoxide dismutase (SOD) activities and glutathione (GSH) level. Liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) were significantly decreased. Urea and creatinine levels (Kidney function) showed no significant changes. Animal’s body weight was significantly decreased through experimental period compared with STZ group results. Histological studies of pancreatic tissue with treatment showed amelioration of atrophy induced by STZ in island of Langerhans cells. Combined treatment of ABP or PM with Cr.Pic showed synergestic effect in treatment of diabetes, on the other hand combined treatment of FA with Cr.Pic showed non-significant changes in biochemical parameters and histological studies compared with STZ group. The data obtained shows that ABP, FA, PM are potential antidiabeteic natural products and antihyperlipidemic associated with diabetes.