الفهرس 
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Abstract
It is now generally accepted that the uterine cervix plays an important role during pregnancy and labor and that it depends on an active ripening process within the cervix. Which is necessary for successful labor induction.
Different methods of cervical ripening have been used including non pharmacological methods as breast stimulation, membrane stripping and amniotomy, pharmacological methods including estradiol, oxytocin, prostaglandins and prostaglandin analogues have been tried.
The ideal cervical ripening agent would include cervical remodeling without stimulating uterine activity and nitric oxide donors are such agents. Prostaglandin analogues namely misoprostol thought effective are associated with side effects such as hyperstimulation and Tachysystole also vomiting, nausea, diarrhea.
The objective of this study was to compare the effectiveness and safety of IMN versus misoprostol for cervical ripening and induction of labor in full term pregnancy.
In this study 141 pregnant females were included for induction of labor. They were divided into three groups each of 47 female. One group received 60mg_SR IMN, the second group received 40mg IMN and the third group received 50 mg misoprostol, all of drugs were applied in posterior vaginal fornix, oxytocin was used as hospital protocol for induction of labor.
Regarding oxytocin requirement it was more required in IMN groups (60,40mg) than in misoprostol group.
There was no significant difference regarding the mode of delivery whether vaginal or cesareans section in both groups.
Regarding indication of cesarean section, Dystocia was more frequent in IMN groups (60,40mg) while non reassuring FHR was more frequent in misoprostol group.
Regarding the adverse effects Tachysystole and hyperstimulation were more frequent in misoprostol group while headach, nausea, vomiting dizziness, hypotension were more frequent in IMN group
Regarding the time needed for vaginal delivery between the three groups it was found that time in misoprostol group was shorter than time in IMN groups (60,40mg).
Regarding NICU requirement there were no significant between IMN and misoprostol group.
The result suggested that IMN less effective than misoprostol but with a fewer adverse effects.