الفهرس 
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Abstract
Present work aimed mainly to study the effect of certain natural
products (total ginger extract, curcumenoids and 10-dehydrogingerdione)
versus atorvastatin on selected atherosclerosis risk factors in rabbits fed
high cholesterol diet.
To fulfill such objectives, the following parameters were selected to
be studied in the serum:-
a) Lipid profile:-
1- TC 2- TAG 3- HDL-C
b) Cholesteryl ester transport protein (CETP) mass
c) Selected cardiovascular (CV) risk factors
1- Ox-LDL 2- MMP9 3- Lp (a)
4- Hs-CRP 5- Hcy
Experimental design:
After 1 week acclimatization rabbits were randomly assigned into 6
groups (n= 6 each). One group received normal chow diet, another group
received high cholesterol diet (HCD) which consists of normal diet
Summary & Conclusion
6-2
supplemented with 0.2% cholesterol dissolved in coconut oil the other
four groups received HCD plus the tested drugs for 6 weeks.
1- Group (1): Normal group (NG):
Rabbits fed normal chow diet and received only coconut oil for 6
weeks (n=6).
2- Group (2): Hypercholesterolemic control group (HC):
Rabbits fed only HCD for 6 weeks and received water with gum
acacia as a placebo.
3- Group (3): Atorvastatin group (Ator.):
Rabbits fed HCD and received ator (20 mg/kg body weight) orally
and daily for 6 weeks.
4- Group (4): Curcumenoids group (Curc.):
Rabbits fed HCD and received Curc (50 mg/kg body weight) orally
and daily for 6 weeks.
5- Group (5): Total Ginger extract group (TGE):
Rabbits fed HCD and received TGE (200 mg / kg body weight)
orally and daily for 6 weeks.
6- Group (6): 10-Dehydrogingerdione group (10-DHGD):
Rabbits fed HCD and received 10-DHGD (10 mg / kg body
weight) daily and orally for 6 weeks.