الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 166 |  |  |
| | | from | 166 | | |
Abstract
Psoriasis is a prevalent dermatological disease affecting about 3% of world population. The disease is disfiguring and disabling in severe cases with impact on patients psychology and affecting the quality of patient’s life. Moreover, psoriasis has been linked recently to cardiovascular risk, diabetes and other elements of metabolic syndrome (Cai et al., 2013; Griffiths and Barker, 2010).The exact etiology of the disease is unknown, however there is evident dysregulated immune response to unknown antigen/stimulus. This dysregulated response occurs in genetically susceptible individual (Mitra et al., 2013).Genetic studies have been involved in psoriasis research since decades. These studies highlighted important pathways in psoriasis development which eventually enabled researchers to develop more efficient therapeutics e.g. Th17/IL23 (Hébert et al., 2012).