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Abstract Administration of DEN and CCl4 only caused significant elevations in the levels of MDA and GSR activity with significant declines in the activities of caspase-3, GPx, GST and SOD and GSH level when compared to control group. This indicates that DEN, CCl4 and their metabolites induced oxidative stress, lipid peroxidation, inflammation and injury of liver and kidney tissuesThe cell components such as lipid, protein, DNA and carbohydrates are affected by free radicals generated during the metabolism of DEN and CCl4. |