الفهرس 
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Abstract
This study was carried out to investigate the possible therapeutic effect of camel milk on induced hepatocarcinogenesis in rats and comparably with other antitumor agent either natural (turmeric extract) or chemical (Cisplatin). This study was carried out to investigate the possible therapeutic effect of camel milk on induced hepatocarcinogenesis in rats and comparably with other antitumor agent either natural (turmeric extract) or chemical (Cisplatin). Induction of hepatocarcinogenesis was intitiated by diethylnitrosamine (DENA) and promoted by phenobarbitone. Body weight was recorded weekly. Whole blood, serum and liver and kidney Samples were collected. Relative liver and kidney weight, Biochemical analysis, hematology, lipid peroxidation and superoxide dismutase (SOD) activity in liver tissue were carried out. Histopathological studies of liver and kidney in addition to immunohistochemical staining of placental glutathione-s-transferase (P- GST) in liver were performed and the results were analysed using image analysis. The albumin concentration was decreased in the groups injected with DENA and was restored in the groups treated with camel milk. Urea and creatinine was elevated in the groups treated with cisplatin. Lipid peroxidation was detected in the group treated with turmeric extract only. The activity of SOD was decreased in the group treated with cisplatin only whereas its activity was restored in the groups treated with camel milk. The mean area of altered hepatocellular foci and the percent area of positively stained P-GST altered foci decreased greatly in the groups treated with camel milk especially in the group treated with cisplatin and camel milk. Hepatocellular carcinoma failed to develop in the groups treated with camel milk. The kidney lesions were mainly chronic interstitial nephritis with thickening of glomerular and tubular basement membrane and were detected in the groups treated with cisplatin. In conclusion, camel milk possessed a good therapeutic effect against induced hepatocarcinogenesis which increased in conjunction with cisplatin whereas turmeric extract had the least therapeutic effect. Camel milk ameliorated the side effects of cisplatin on the kidneys. However, camel milk could be recommended to patients suffering from hepatic tumors.