الفهرس 
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Abstract
Sepsis is a significant cause of morbidity and mortality in neonates (Stoll; 2004). Neonatal sepsis may have subtle, diverse and nonspecific symptoms and signs; moreover, a delay in the diagnosis and commencement of treatment results in a high morbidity and mortality (Ahmed et al; 2005).
The inadvertent use of broad-spectrum antibiotics has led to the emergence of multi-drug resistant Gram-negative bacteria (Koksal et al; 2002). Klebsiella species are of significant importance in this regard (Roilides et al; 2000). The most common pathogens of bacterial sepsis and antibiotic sensitivity patterns vary in different parts of the world (Maksic et al; 2002, Luck et al; 2003 and Waheed et al; 2003). A specific antibiotic choice must be driven by hospital-specific guidelines based on the major causes of sepsis and organism susceptibility patterns in that specific hospital (de Man et al; 2000). Knowledge of local epidemiology is required for optimal management of neonatal sepsis.
The present study was performed to study the prevalence and the risk factors of neonatal sepsis also the antibiotic use and misuse in the NICU of Suez Canal University Hospital using the Egyptian neonatal network data definitions, in order to establish and maintain database of neonates which will be a base for quality improvement and management at our Neonatal intensive care unit aiming for future policy planning and development.
The study included 90 neonates who were diagnosed as neonatal sepsis whether from the beginning of admission course or during their stay in the 1st 28 days of life. The study was conducted on three groups each one (30) neonates, the 1st group culture based sepsis, the 2nd group clinically diagnosed sepsis and the 3rd group clinically suspected sepsis, it was conducted in the period from October 2012 to June 2013. The total number of cases admitted in this period was 367 neonates of which 90 neonates diagnosed as neonatal sepsis representing (24.5%) of the total