الفهرس 
Introduction & Aim of the work
Anatomy Of The EyeOnly 14 pages are availabe for public view
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Abstract
This study was carried out on sixty patients ASA physical state I & II, aged between 18-65 years undergoing intraocular surgery. Both administration of medication and collection of data were performed in double blind manner.
The aim of study was to evaluate the effect of dexmedetomidine 0.5 μg/kg IV as a single bolus dose versus the effect of fentanyl 1μg/kg IV as a single bolus dose on the quality of extubation, intraocular pressure, hemodynamic responses during extubation, the level of postoperative sedation and analgesia and the prevalence adverse events.
Group (I): received 10 ml of isotonic solution as a single bolus dose 5 min before extubation over 60 second as a placebo (control group).
Group (II): received fentanyl 1 μg/kg I.V in 10 ml of isotonic solution as a single bolus dose 5 min before extubation over 60 second (fentanyl group).
Group (III): received 0.5 μg/kg I.V dexmedetomidine 10 ml of isotonic solution as a single bolus dose 5 min before extubation over 60 second (dexmedetomidine group).
The variables included: HR, SBP, DBP, MAP and O2 saturation were checked before induction, at the end of surgery, 1min, 3min after drug administration, at extubation, 1min, 3min, 5min and 10 min after extubation. Also Intraocular pressure, extubation quality using a 5-point scale, , Extubation and recovery time, postoperative pain, postoperative sedation, airway complication and adverse events were recorded.
The results of this study found that the hemodynamics SBP, DBP, HR and MAP had insignificant changes between the readings preoperatively, at the end of the surgery among the 3 groups. But we noticed that there were significantly lower increases in HR, SBP, and DBP, MAP after drug adminstration in patients who received dexmedetomidine compared with those who received fentanyl and also both groups were significantly lower than control group.
The extubation quality was significantly better in dexmedetomidine group than fentanyl group and both groups were significantly better than the control group.