الفهرس 
Supervision sheetOnly 14 pages are availabe for public view
 |  | from | 242 |  |  |
| | | from | 242 | | |
Abstract
The wide environmental distribution of Cr leads to an increased interest
of its toxicity and biological effects. This study was conducted to investigate
the possible protective effect of Spirulina platensis and/or radish oil against chromium-induced toxicity and carcinogenecity. Eighty four adult male Albino rats were divided into 7 equal groups (Gps). Gp1 served as a control, Gps 2 , 3
and 4 exposed to Spirulina platensis (300 mg/kg b.wt per os) , radish oil (0.07 ml/kg b.wt per os) and sodium dichromate dihydrate (SDD) (via drinking water at concentration of 520 mg /l), respectively, for 3 months.
While, Gp5,6,7 rats exposed to SDD concomitantly with Spirulina , radish oil, both respectively with the same previously mentioned doses, routes and
duration of exposure. chromium administration caused significant alterations in the hematological parameters, serum iron and AFP as well as hepatic and renal function markers that was objectified by significantly increased Alanine transaminase (ALT), Alkaline phosphatase (ALP), urea and creatinine levels accompanied with significantly increased MDA level, decreased catalase activity as well as glutathion content in blood and hepatic tissue homogenates. In addition to increased chromium residues in both blood, liver and kidney Histologically, Cr provoked a multisystem functional alterations that were proved by changes in the histological structure of the different investigated organs accompanied with positive PCNA in kidney and urinary bladder. Morphometrical measurements revealed glomerular and tubular alterations
with increased DNA content and DNA ploidy in kidney sections .On contrary,
the co-treatemnt with spirulina and/or radish oil with SDD significantly
restored the hematological, biochemical parameters and AFP level as well as
all the previously mentioned pathological changes as well. In conclusion, Spirulina Platensis and radish oil exhibited protective antioxidant effects against chromium-induced toxicity and carcinogenicity in male albino rats.