![]() | Only 14 pages are availabe for public view |
Abstract The present study aimed to evaluate fecal calprotectin as a valuable non invasive marker in distinguishing gut pathogens in young children with acute gastroenteritis as early predictor of bacterial inflammation. The study was carried on 90 child (1-36 months ) selected from the Pediatric Department of Children’s University Hospital at Minia University during the time period from June 2012 to December 2012. Studied infants and children were divided into ; Group A (acute gastroenteritis = AG ) ; A1- BAG (bacterial growth were found in 19 cases as follow ; 6 proteus spp ,6 salmonella spp , 4 E-Coli ,3 shigella spp). A2- NBAG (no bacterial growth were found in this group = 41 cases Group B ( controls ) It consists of 30 child aged 1-36 months divided in two groups as Follows ; 1- infants (1-12 months ) . 2- young children (12-36 months ) . All children included in the study were subjected to Full history taking , thorough clinical examination, laboratory investigation as ESR, CRP and WBCs . stool culture was done to detect bacterial growth and f-cp was measured in stools by ELISA technique . Results: 1- f-cp is higher in BAG than NBAG and controls; • The median and IQR in BAG are 225.61(198.72-263.28) , • The median and IQR in NBAG are 59.76(51.95-69.76) , • The median and IQR in controls are 36.31(32.71-37.22) , 2- CRP is higher in BAG than NBAG ; The median and IQR in BAG are 48 (36-90) The median and IQR in NBAG are 5 (3-7.5) 3- ESR is higher in BAG than NBAG ; The median and IQR in BAG are 22(18-34) The median and IQR in NBAG are 6(4-9) 4- WBCs are higher in BAG than NBAG The median and IQR in BAG are 11.80(10.60-13.10) The median and IQR in NBAG are 5.20±(4.80-7.85) |