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العنوان
Synthesis of some new heterocyclic compounds containing pyridine moiety and evaluation of their biological activity /
المؤلف
Muhammad, Tresk Kadir.
هيئة الاعداد
باحث / تريسك قادر محمد
مشرف / أحمد على حامد سعد فضة
مشرف / إيمان حلمى توفيق رجب
مشرف / أحمد على حامد سعد فضة
مشرف / إيمان حلمى توفيق رجب
الموضوع
Organic compounds - Synthesis. Pyridine.
تاريخ النشر
2014.
عدد الصفحات
187 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
01/01/2014
مكان الإجازة
جامعة المنصورة - كلية العلوم - Department of Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

The reaction of 2-cyano-N’-(pyridin-4-ylmethylene) acetohydrazide (1) with phenyl isothiocyanate gave thiocarbamoyl derivative 3 which reacted with α‐halocarbonyl compounds in N,N‐dimethyl formamide in the presence of triethyl amine to afford thiazoles 6, 9, 11, 13, 15 and thiophene 8 derivatives, while when the same reaction was stirred in N,N‐dimethyl formamide, it only afforded the acyclic compounds 4, 7, 10, 12 and 14 which when refluxed in N,N‐dimethyl formamide in the presence of triethyl amine, they gave the corresponding above thiazole and thiophene derivatives. The newly synthesized compounds were characterized by analytical and spectral data.