الفهرس 
Vascular Anatomy of the LiverOnly 14 pages are availabe for public view
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Abstract
T
he aim beyond this study was to evaluate the validity of fibroscan and some of other non-invasive methods in identifying the degree of fibrosis in 25 Budd Chiari syndrome patients.
To fulfill such purpose, all patients were subjected to detailed history taking, clinical examination and laboratory investigations including: liver profile, kidney function tests, complete blood picture, viral markers and laboratorary tests to determine the possible etiology. Upper GI endoscopy was performed to evaluate the status of varices and portal hypertensive gastropathy, liver biopsy which is considered as the gold standard for fibrosis staging and fibroscan which is the tool under study.
The current study revealed that the participiants’ age ranged between 14 to 45 years with a mean of 28.52 ± 8.33, with females representing 52% of cases.
The mean MELD score was 14.32±3.35, the mean Child score was 9.48±1.42, with 52% of cases were Child B, 48% Child C, none were Child A, while the mean Rotterdam score was 1.18±0.37. There was no significant relation between the mentioned scores and the status of fibrosis.
Regarding laboratory findings, there was no significant relation between fibrotic and non fibrotic participants as regard all laboratory data except WBCs.
Based on liver biopsy results, F2 was the most frequent degree of fibrosis (32%) and about 56% of cases had no liver fibrosis ≤F2. However fibroscan revealed F4 among all cases (100%).
Being a constant, fibroscan could not be assessed as a non-invasive method for diagnosis of liver fibrosis in BCS patients.
The current study also proved that there is no statistical relation between status of fibrosis and any of APRI score, FIB-4 score, API score. APRI score and FIB-4 score could not discriminate between cases with fibrosis and cases without. Only AAR score was found to have a statistical relation with liver fibrosis and could fairly discriminate cases with fibrosis from cases without at 1.3 cut-off value with 72.7% sensitivity and 78.6% specificity.