الفهرس 
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Abstract
Pre-eclampsia is a syndrome that is characterized by an inability of the
trophoblast to invade the decidual arteries leading to alterations in placental
development, placental perfusion and an insufficient transport of nutrients. It is a major
cause of maternal and fetal morbidity and mortality and affects 7-10% of pregnancies.
HMGB1 (High Mobility Group Box 1) is an intracellular protein that can
translocate to the nucleus where it binds DNA and regulates gene expression. It can
also be released from cells, in which extracellular form it can bind the inflammatory
receptor RAGE (Receptor for Advanced Glycan End products]. Release from cells
seems to involve two distinct processes: necrosis, in which case cell membranes are
permeabilized and intracellular constituents may diffuse out of the cell; and some form
of active or facilitated secretion induced by signaling.
The aim of this study was to evaluate serum level of peripheral ligand high
mobility group protein B1(HMGB1)in relation to the onset and severity of preeclampsia.
The study was carried out on ninety patients attending the antenatal care clinic
of El-Shatby Maternity University Hospital in Alexandria.
Cases were divided to three groups:
Group I: included thirty patients with normally ongoing pregnancies.
Group II: included thirty patients with mild preeclampsia:
Group III: included thirty patients with severe preeclampsia or impending eclampsia.
Estimation of the serum concentration of HMG B1 by using HMGB1 ELISA Kit
Our results summarized that:
- HMGBI group II and III have values statistically higher than control group.
- There were negative significant correlation between HMGB1 with platelets.
While, there were no statistical significant correlation between HMGB.