الفهرس 
CHRONIIC RENAL FAIILURE AND HEMODIIALYSIISOnly 14 pages are availabe for public view
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Abstract
T
his study aimed to evaluate serum sRAGE levels in pediatric CRF patients, also their relation with inflammation.
This study comprised:
1- Fifteen CRF patients under regular conservative therapy. They were 11 males and 4 females. Their age ranged from 1-14 years with mean age of 8 + 2.8 years.
2- Fifteen CRF patients under regular hemodialysis. They were 8 males and 7 females. Their age ranged from 5-17 years with mean age of 12.5+3.5.
3- Twenty age and sex matched healthy individuals were included as a control group. Their age < 18 years with mean age of 9.2+4. They were 10 males and 10 females.
All those children were subjected to detailed history, clinical examination, renal functions (serum creatinine, BUN and GFR), serum sRAGE and hs CRP levels.
Also our study showed correlation between serum sRAGE levels with parameters of renal functions in patients with chronic renal failure. The parameters included: age of patients, age of onset of disease, duration of disease, creatinine, BUN and GFR. There was significant correlation between their levels and renal functions as follows: positive correlation with age of patients, age of onset of disease, duration of disease, BUN and creatinine, and negative correlation with GFR as supported by P value <0.001.
The mean values of weight and height were significantly lower in CRF patients than in control groups, with P value <0.001.
There was a significant negative correlation between serum sRAGE levels with weight and height among CRF patients as supported with P value <0.05.
Also there was a significant positive correlation between levels of sRAGE versus SBP and DBP among HD patients as evident by P value < 0.001.
The hs CRP levels were elevated in our patients with CRF than control group where P value < 0.05.
We can conclude that mean value of sRAGE was higher in CRF patients than in control group, and their levels is higher in HD group than in conservative group as supported by P value <0.001.
The hs CRP levels were elevated in our patients with CRF than control group. We didn’t find a significant correlation between sRAGE and CRP and thus we couldn’t find a relationship between sRAGE and inflammation. So future studies should concentrate on long term follow up of the effect of elevated serum levels of sRAGE on CKD patients and its progression.