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Abstract MSG consumption has some deleterious effects on the cerebellum of adult rats at higher doses and by extension can affect the functions of the cerebellum. The pathogenesis of cerebellar ataxia is continuously expanding. Identification of mechanisms underlying cerebellar disorders represents a combination of key factors for the development of anti-ataxic innovative therapies. Traditional treatment of neurological lesions represents a medical challenge but in recent years, new cell replacement therapy has received considerable attention, intensified by increasing number of potential cell sources for transplantation. The stem cells used in most of the previous studies were injected locally into cerebellar hemispheres but, little information is available regarding the therapeutic potential of systemically delivered cells on cerebellar ataxia. Aim of the work: This study was designed to improve the cerebellar damage induced by monosodium glutamate by using human umbilical cord blood stem cells; CD34+ versus CD34- in adult female rats. |