الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Inflammatory bowel disease either Crohn’s disease or ulcerative colitis are the main cause of IBD. Their etiology and pathogenesis remains unclear but it seems to be multifactorial. The main factors are genetic factors, environmental factors, and immunological factors.
The ulcerative colitis disease affects only the colon with continuous symmetrical involvement. The endoscopic features include: the mucosa appears hyperemic, edematous and granular in mild disease when the disease progresses the mucosa become heamorrhagic with visible punctuate ulcers and the patients may develop acute mega colon. The microscopic features include: edema of the lamina propria, congestion of the capillaries and this is followed by acute inflammatory cell infiltrate of neutrophils, lymphocytes, plasma cells, and macrophage.
Ulcerative colitis can be presented by chronic diarrhea, abdominal pain, weight loss, malnutrition, bleeding per rectum, anorexia, nausea, perianal symptoms or extra intestinal symptoms like anemia, eye involvement, skin disorders like erythema nodosum, pyoderma gangrenosum and primary sclerosing cholangitis.
Diagnosis can be done by laboratory findings (complete blood count, CRP, and ESR), endoscopy, histopathology, radiology (CT enterocolonography, MRI enterocolonography).
The aim of the current study is to evaluate the validity of Ulcerative Colitis Endoscopic Index of Severity in the evaluation of Ulcerative Colitis.
This study included eighty patients with established diagnosis of Ulcerative colitis. They were collected at Gastroenterology unit, Internal Medicine Department of the Main University Hospital of Alexandria.