الفهرس | Only 14 pages are availabe for public view |
Abstract Several 0- and S-quinoxalineglycosides ha ve been prepared by glycosidation of 3-methyl-2-oxo(thioxo)-1,2-dihydroquinoxaline Ja,b with a-D- glucopyranosyl, a-D-galactopyranosyl and a-D-lactosyl bromide in presence of K2C03follov.ed bydeacetylation with Et3NIH2o. Furthermore, alkylation ofJa,b with 4-bromobutyl acetate, 2-acetoxyethoxymethyl bromide and 3-chloropropanol afforded the corresponding 0- and S-acycJoquinoxaline nucJeosides. The structure of the new synthesized compounds was confirmed by using IR, IFf, J3C NMR spectra and microanalysis. Some of these synthesized compounds were screened in vitro for antitumor and antimicrobial activity. |