الفهرس 
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Abstract
The present study comprised 102 randomly selected cases of primary colorectal carcinomas which were taken from the archives of histopathological laboratories of Minia University Hospital and National Cancer Institute of Cairo (In the period between 2004 and 2012). The cases included; 59 (57.8 %) cases of adenocarcinoma, 28 (27.5%) cases of mucoid carcinoma and 15 (14.7%) cases of signet ring cell carcinoma. Another 45 tissue sections of adjacent normal colorectal epithelium (available blocks) were immunostained as the control group. In addition, 34 of metastatic malignant lymph nodes for lymph node positive cases were also included in the study. On studying the cytoplasmic expression of Ezrin, the expression was significantly higher in colorectal carcinoma compared to normal tissues. Cytoplasmic Ezrin expression was significantly higher in lymph node positive than lymph node negative cases and in cases with lymphovasular invasion than cases without invasion. Similarly, there were significant variations in cytoplasmic Ezrin expression among different stages of colorectal carcinoma being markedly higher in tumors with advanced TNM and Dukes stages compared to lower stage tumors. As for adenocarcinoma cases, grade III tumors showed more frequent strong cytoplasmic Ezrin expression than grade I and II however, such differences did not reach the significant statistical level (p value= 0.2). No significant associations were also observed between cytoplasmic Ezrin expression and patients’ age, gender, tumor size, location, tumor type, perineural invasion, tumor budding or tumor infiltrating lymphocytes. Regarding membranous Ezrin expression, statistically significant positive associations were detected between membranous expression of Ezrin and nodal metastasis, advanced TNM stage and Dukes stage. No significant associations were observed with other parameters. On comparing cytoplasmic and membranous Ezrin expression in primary tumors and their corresponding metastatic lymph nodes, no significant differences were observed in Ezrin expression between both locations. Concerning cytoplasmic ICAM-1 expression, this work identified significant differences in expression between different types of colorectal carcinoma being markedly higher in adenocarcinoma compared to mucoid and signet ring subtypes. Among adenocarcinoma cases, a significant inverse association was found between cytoplasmic ICAM-1 expression and tumor grade where ICAM-1 expression scores were significantly higher in grade I than grade II and III tumors. Statistically significant inverse associations were found between cytoplasmic ICAM-1 expression and both TNM and Dukes staging systems and lymphovascular invasion. However, statistically significant positive associations were found between cytoplasmic ICAM-1 expression and both tumor infiltrating lymphocytes and tumor budding. No significant associations were found between cytoplasmic ICAM-1 expression and other clinicopathologic features. With respect to membranous ICAM-1 expression, a significant positive relationship was found between membranous ICAM-1 expression and tumor grade where 80 % of cases showing positive membranous ICAM-1 expression were of grade III. No significant associations were found between membranous ICAM-1 expression and other clinicopathologic features. Comparing ICAM-1 expression in primary tumors and their corresponding metastatic lymph nodes revealed no significant differences in ICAM-1 expression scores between primary tumors and their matched lymph node metastasis. Ezrin and ICAM-1 immunoreactivity results did not display significant association between both markers in this series of colorectal carcinoma cases.