الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Cis-Diammineplatinum (II) dichloride (cisplatin) is the important anti-cancer agent useful in treatment of various cancers. Unfortunately, it can produce unwanted side effects in various tissues, including the liver and kidneys. The present study investigated the possible protective role of curcumin and vitamin C against side effects of cisplatin treatment. 90 Male Wistar albino rats were divided into nine groups (n = 10). The 1st (normal control group) received distilled water. The 2nd (Saline group) injected interperitoneal with physiological saline. The 3rd (Gum acacia group). The 4th (Curcumin treated group), rats were given curcumin (20 mg/kg b.wt). The 5th (Vitamin C treated group), received vit. C (100 mg/kg b.wt). The 6th (Cisplatin treated group), rats were intraperitoneal (i.p.) injected with cisplatin(0.4 mg/kg body weight b.wt). The 7th (Cis + vitamin C treated group), The 8th (Cis + Cur treated group) and The 9th (Cis + vitamin C + Cur treated group), rats were pre-treated with a single dose of vitamin C (100 mg/kg b.wt), curcumin (20 mg/kg b.wt) and combined vitamin C with curcumin, respectively, for 20 minute prior the administration of cisplatin. After 60 day of first injection, blood and specimens were collected. Blood picture, lipid profile picture, blood glucose level, ALT, AST, total protein, albumin, globulins, creatinine, urea, uric acid, testosterone, lipid peroxidation biomarker (MDA) and some antioxidants enzymes(SOD, CAT and GSH) were investigated. Cisplatin revealed a significant decrease in RBCs count, WBCs count, Hb% and hematocrit values. In addition, significant increase of hepatic malondialdehyde (MDA) levels and a significant reduction of hepatic superoxide dismutase (SOD), catalase activities and GSH level compared to the saline group. Cisplatin treated group elicited a marked increase of the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and decreasing in total protein, albumin and globulins levels. It also demonstrated a significant increase in creatinine, urea and uric acid compared to its control saline group. In addition blood glucose level significantly decrease, serum cholesterol and triglycerides level significantly increased as well as testosterone level significantly decreased. Pre-treatment with combined curcumin and vitamin C improved the blood picture, kidney function, liver enzymes, lipid peroxidation biomarker, lipid profile, glucose and testosterone level as well as antioxidant enzymes. The findings indicate that pre-treatment with combined curcumin and vitamin C succeeded in ameliorating or reducing the possible side effects of treatment with cisplatin.