الفهرس | Only 14 pages are availabe for public view |
Abstract ro hepcidin is the 60 a pro-hormone form of hepcidin. Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the degradation of, ferroprotin, the sole known iron exporter in iron transporting cells. Hepcidin is not only an iron-regulatory hormone but also an important link between host defense and iron metabolism. The aim of the current study was to determine serum levels of pro-hepcidin using ELISA in full-term and preterm newborns with sepsis and to determine the possible relationships between pro-hepcidin levels and serum iron and complete blood count. This study conducted on 40 neonates diagnosed as having sepsis and 40 healthy neonates with no clinical signs or laboratory evidence for sepsis serving as a control group. All neonates included in this study were subjected to: Full history taking from their mothers, full clinical examination of the babies. Laboratory was done as CBC, CRP, and Iron profile and serum prohepcidin level. The results of the current study revealed that: There was statistical significant in chorioamnionitis and PROM as a risk factor in septic groups compared to controls. There was statistical significant of respiratory distress as a clinical sepsis in septic compared to controls (preterm only). There was significant statistical increase in rodwell score as a laboratory sepsis in septic compared to controls, In CBC There was statistical significant of total Platelet count, immature to total (I:T) PMN ratio , immature to mature (I:M) PMN ratio and immature PMN count in septic compared to controls, also There was highly statistical significant for both Hb and Hct in septic compared to control group. There was significant statistical increase of iron profile (total iron, transferrin, total iron binding capacity) in septic compared to control group and in septic full term compared to septic preterm. There was significant statistical increase of serum prohepcidin between septic and control group and between septic full term and septic preterm and There was significant correlation between serum prohepcidin level and chorioamnionitis as a risk factor for sepsis serum prohepcidin was significantly related to serum iron transferrin level but no correlation between prohepcidin and serum ferritin nor total iron binding capacity. Also there‟s significant correlation between total iron binding capacity, ferritin and immature/total leucocyte ratio with chorioamnionitis as a risk factor for neonatal sepsis. |