الفهرس 
Effects of inflammation on erythropoiesis and iron homeostasis in mammalsOnly 14 pages are availabe for public view
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Abstract
ro hepcidin is the 60 a pro-hormone form of hepcidin.
Hepcidin inhibits the cellular efflux of iron by binding to,
and inducing the degradation of, ferroprotin, the sole known iron
exporter in iron transporting cells.
Hepcidin is not only an iron-regulatory hormone but also
an important link between host defense and iron metabolism.
The aim of the current study was to determine serum
levels of pro-hepcidin using ELISA in full-term and preterm
newborns with sepsis and to determine the possible relationships
between pro-hepcidin levels and serum iron and complete blood
count.
This study conducted on 40 neonates diagnosed as having
sepsis and 40 healthy neonates with no clinical signs or
laboratory evidence for sepsis serving as a control group.
All neonates included in this study were subjected to:
Full history taking from their mothers, full clinical
examination of the babies.
Laboratory was done as CBC, CRP, and Iron profile and
serum prohepcidin level.
The results of the current study revealed that:
There was statistical significant in chorioamnionitis and
PROM as a risk factor in septic groups compared to controls.
There was statistical significant of respiratory distress as a
clinical sepsis in septic compared to controls (preterm only).
There was significant statistical increase in rodwell score
as a laboratory sepsis in septic compared to controls, In CBC
There was statistical significant of total Platelet count, immature
to total (I:T) PMN ratio , immature to mature (I:M) PMN ratio
and immature PMN count in septic compared to controls, also
There was highly statistical significant for both Hb and Hct in
septic compared to control group.
There was significant statistical increase of iron profile
(total iron, transferrin, total iron binding capacity) in septic
compared to control group and in septic full term compared to
septic preterm.
There was significant statistical increase of serum
prohepcidin between septic and control group and between
septic full term and septic preterm and There was significant
correlation between serum prohepcidin level and
chorioamnionitis as a risk factor for sepsis serum prohepcidin
was significantly related to serum iron transferrin level but no
correlation between prohepcidin and serum ferritin nor total
iron binding capacity. Also there‟s significant correlation
between total iron binding capacity, ferritin and
immature/total leucocyte ratio with chorioamnionitis as a risk
factor for neonatal sepsis.