الفهرس 
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Abstract
A comparative study of cardio protective effect of aliskiren, telmisartan and torsemide was carried out on L-nitro arginine methyl ESTER (L-NAME) - induced hypertension in rats. The degree of protection was assessed by measurement of systolic blood pressure and heart rate of animals every two weeks by noninvasive blood pressure from the tail of conscious rats by the tail-cuff technique. Heart rate was recorded automatically by a counter triggered by the pulse wave. At the end of the experimental period (8 weeks) blood sampling was carried out for estimation of the level of NO2 - /NO3- .After that animals were sacrificed for heart dissection to detect collagen type I and III gene expression. Also histopathlogical study was done using Hematoxylin and Eosin as a basic stain and collagen-specific stain Masson’s trichrome is used to evaluate the extension of collagen deposits. Three drugs were given P.O daily for 8 weeks in a dose of 30 mg/kg /day for aliskiren and 10 mg/kg/day for telmisartan while torsemide was given in a dose of 0.2 mg/kg orally every 12 hours. The selected drugs were given simultaneously with L-NAME 50 mg/kg per day orally. In conclusion this study revealed that the three drugs aliskiren, telmisartan and torsemide decreased blood pressure significantly compared to L-NAME. There is no significant difference between aliskiren and telmisartan in all measurements. There were insignificant changes in pulse rate values between the three L-NAME treated groups through the experiment. The three drugs significantly increase NO compared to L-NAME. Collagen I and III were significantly decreased by the three drugs but the highest percentage of inhibition was with telmisartan compared to L-NAME. Comparing the percentage inhibition of fibrosis between the three L-NAME treated groups, there was insignificant difference between telmisartan and torsemide treated groups while both are superior to aliskiren.