الفهرس 
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Abstract
a prospective study undertaken at the Internal Medicine Department and Gastroenterology Endoscopic Unit of Suez Canal university hospital. Forty patients underwent ERCP for any cause (diagnostic or therapeutic) was included in the study. All patients were subjected to complete clinical evaluation [history and physical examinations] and laboratory investigations [complete blood count, liver enzymes (ALT and AST), serum creatinine, random blood sugar, serum amylase and IL-10].
The prevalence of PEP in the studied patients was 22.5%. The mean age of the patients was 53±15.9 years with a range of 22-82 years. Patients with PEP had a statistically significant lower mean age than patients without PEP (43.4 years versus 55.7 years, respectively) (p<0.05). The frequency of males in PEP was higher than the frequency of females (55.6% versus 44.4%, respectively) but without significant difference (p>0.05). The frequency of patients with PEP who lives in rural areas was significantly higher than the frequency of patients without PEP (55.6% versus 12.4%, respectively) (p<0.05). Occupation, marital status and smoking history show insignificant differences between both studied groups (p>0.05).
The percentage of diabetes in the whole studied patients was 17.5%, the percentage of hypertension was 22.5% and the percentage of cancer was 30%. The prevalence of diabetes mellitus, hypertension and cancer show insignificant differences between both studied groups (p>0.05).
The most common clinical manifestations of the studied patients were biliary colic (100%), followed by jaundice (95%). The percentage of vomiting in the whole studied patients was 62.5% and the percentage of weight loss was 45%. All these clinical manifestations show insignificant differences between both studied groups (p>0.05).
The percentage of post-ERCP vomiting, abdominal pain and tenderness were higher in patients with PEP than in patients without PEP (100%, 100% & 88.9% versus 6.5%, 3.2% and 3.2%, respectively) (p<0.0001).
As regards ERCP findings, duodenal papillae, IHR, and IHL were bulky in 25%, 30%, and 30% of the patients, respectively. Calcular cholecystitis and neoplastic obstruction were presented in 60% and 40% of the studied patients, respectively. As regards ERCP procedures, stone extraction was performed in 40% of the patients while stent insertion was performed in 60% of them. There were no statistically significant differences between both studied groups regarding ERCP findings and procedures (p>0.05).
There were no statistically significant differences between both studied groups regarding all laboratory investigations (p>0.05), except serum amylase. The mean serum amylase level was significantly higher in patients with PEP than in patients without PEP (783.4 versus 69.7, respectively).
There were significant correlations between the presence of PEP and younger age and rural residence (p<0.05). All other variables show insignificant correlations with the presence of PEP (p>0.05).
There were significant positive correlation between IL-10 and AST levels (p<0.05). All other variables show insignificant correlations with IL-10 levels (p>0.05).
The optimal cutoff point of IL-10 to detect the presence of PEP was measured (>1.1 pg/dl) with a sensitivity of 33.3%, specificity of 90.3%, positive predicted value (+PV) of 50% and negative predicted value (-PV) of 82.4%.