الفهرس 
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Abstract
GERD is a normal physiological phenomenon
experienced intermittently by most people, particularly after
meals it occurs when the amount of gastric juice that refluxes
into the esophagus exceeds the normal limit causing symptoms
either with mucosal injury i.e. esophagitis(GERD)or without
remarkable oesphageal lesion i.e. non erosive reflux disease
(NERD).
GERD is one of most complication of obesity and it is
highly related to BMI. The precise pathophysiological link
between obesity and GERD has not been fully elucidated.
Individual studies have variably found reduced lower
esophageal sphincter (LES) pressure, increased frequency of
transient LES relaxations, increased prevalence of hiatal hernia,
an increased prevalence of esophageal motor disorders, and
disorders of gastric accommodations in obese subjects. Elevated
intragastric pressure in patients with central obesity has also
been implicated as a contributing factor.
The pathophysiology of GERD in patients who are
morbidly obese might differ from that of patients who are not
obese So that the correction of reflux in patients who are
morbidly obese might be better achieved with a procedure that
first controls obesity. Aim of work is to assess the possible role of IL6in GERD
patients with and without obesity.
IL-6 is an interleukin that acts as both a pro-inflammatory
and anti-inflammatory cytokine. It is secreted by T cells and
macrophages to stimulate immune response
Studies have focused that visceral fat is metabolically
active and produce variety of cytokines including IL-6 and TNF
which may affect osephagogastric motor activity.
.we evaluated serum IL6 is an inflammatory mediator in
individual with GERD.
This study was conducted on (90) patients:
Group (1): Twenty five patients GERD and obese.
Group (2): Twenty five patients GERD and non obese.
Group (3): Twenty five patients NERD and obese.
Group (4): Fifteen patients NERD and non obese.
The result are statically and we observed the following :
Severity of GERD is increase by increase of age probably
as the result of cumulative acid injury over time to
esophagus.
GERD was equal in both male and female , no sex
prdimonace There is no significant relation between IL6 and central
obesity
There is no significant relation between IL6 and BMI
There is no significant relation between BMI and severity
of GERD or finding of upper endoscopy
There is no significant relation between waist
cicumferance and IL6.
There is significant relation between IL6 and upper GIT
endoscopy finding IL6 level increase in barret esophagus
and low in negative finding
IL6 can be used as predictor for severity of upper GIT
finding in patient complaining of GERD