الفهرس 
Anatomy & Physiology of the liverOnly 14 pages are availabe for public view
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Abstract
The study was done to evaluate the efficacy of measuring serum Telomerase activity (hTERT mRNA), HGF, FGF and PD-GF for early diagnoses and prediction of HCC and for prediction of invasion and recurrence.
The present study included 49 subjects (31 males and 18 females). All studied persons were attending the Tropical Medicine Department and HCC Outpatient Clinic, Ain Shams University Hospitals, Cairo, Egypt, and Dar El-Fouad Hospital, October, Giza, Egypt, and were subjected to clinical and laboratory examinations before being selected in the present work.
The studied persons were divided into three groups
Control group: included 9 healthy individuals (3 males and 6 females). Their age ranged from 36-43 years with mean (39±3.04).
Group (I): 30 HCC proven patients with Child Pugh score: A & B (21 males and 9 females).Their age ranged from 32-65 years with mean (53±8.7).
Group (II): 10 chronic hepatitis patients with or without cirrhosis (7 males and 3 females). Their age ranged from 29-62 years with mean (47±10.5).
All cases were subjected to history taking, clinical examination, routine investigations, Ultrasound, CT scan,liver function tests,CBC, and measuring of biological markers Telomerase activity (hTERT mRNA), HGF, FGF and PD-GF.
Regular follow up was done for all cases including history examinations laboratory investigations after treatment and surgery.
The results were subjected to statistical analysis, the analysis showed that the studied group included 31 males and 18 females whose age range was from 29-65 years.
The results obtained were statistically analysed and can be summarized as follows
1. A significant increase in Telomerase activity (hTERT mRNA) and serum levels of HGF in HCC group when compared with chronic hepatitis group and control group, and increase in serum levels of bFGF in HCC group and chronic hepatitis group when compared with control group, while no significant increase was seen in serum levels of PD-GF when the 3 groups were compared.
2. A significant deterioration in liver functions test PT, AST, ALT, ALK, T.Bilirubin and Albumin in HCC group and chronic hepatitis group when compared with control group.
3. A significant correlation between Telomerase activity (hTERT mRNA), bFGF and PD-GF levels and grading of HCC (poorly differentiated tumors are accompanied by rise in the levels of biomarkers).
4. A significant correlation between Telomerase activity (hTERT mRNA) and HGF levels and also a significant correlation between Telomerase activity (hTERT mRNA) and deterioration of some of liver functions tests, similarly there were significant correlation between HGF and some liver functions tests.