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Abstract During the past two decades, considerable attention has been paid to the chemistry of the transition metal complex. It has been suggested that the presence of metal ions in biological fluids could have a significant effect on therapeutic action of drugs. The successful synthesis and application of novel metal complexes can have a great impact on all areas of chemistry and biology. So we have synthesis some complexes containing nucleous molecule which have a widely known concerning the biological application in our life to study them. As yet from the literature survery, little information is available about the compounds, which are effective as coordinating ligands with the functional sites amino, hydroxyl, carbonyl and carboxyl groups. In view of the biological, physic-chemical properties and industrial importance of these ligands and their metal complexes, the aim of the present work is to shed light on: Understanding the nature of interaction and chelation between metal ions and these ligands. Investigation the physic-chemical properties of the ligand and their metal complexes. Screening of the ligands and their metal complexes for their biological activity. In the present work, we synthesize metal complexes and study the mode of coordination between metal ions and organic ligand. Also we use different tools of analysis like elemental analysis CHN, Infrared and electronic spectra , 1HNMR and conductivity measurements. The study of thermogravimetric analysis (TGA) as well as kinetic parameters gives an idea about thermal stability of the prepared compounds. Finally the biological activity of the formed compounds was screened. |