الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
I-N. TRODUCTION AND AlM OF THE ~ ,------·-~--- --- _____ ,,_ -------------- --· -·-·- --
Glycosylated haemoglobin (HbAlc) is r 0 rmed
as result of a slaw post-translational conversion
of adult haemoglobin throughout the red ce l l
life span. In support of this osbervation is
the fact that old red cells have higher levels
of HbAlc than do young red cells and the concentrat
ion of HbA 1 c decreases in erythrocytes of patients
with haemolytic anaemias because of their short
survival time (Horton and Huisman, 1965, Bunn,
et al., 1976 and McFarland, 1981).
Recently, Krause e t a l • (1982), Svendsen
and S,Jegaard (1982) studied the relationship
be tween foetal haemoglobin and glycosylated
haemoglobin. Moreover, Yatscoff and his coworkers
(1983) reported that high level of HbF interferes
with determination of HbAlc by column chromatography
as i t coelutes with glycosylated haemoglobin
producing false high levels. The same authors
advised the measurement of HbF in conjunction
with HbAJc and correcting the latter far the
presence of HbF or the use of other methods with
which HbF does not interfere. Thus, the aim of
the present study is to measure the level of
glycosylated haemoglobin in a group of patients
suffering from congenital haemolytic anaemias
in a trial to correlate this level with HbF.