الفهرس 
Peripheral nervesOnly 14 pages are availabe for public view
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Abstract
Peripheral nerve problems are common and encompass a large spectrum of traumatic injuries, diseases, tumors and iatrogenic lesions. Despite early diagnosis and the use of modern surgical techniques, no matter how accurate the nerve repair, function recovery can never reach the pre-injury level. Poor outcome may result from many factors, both intrinsic and extrinsic to the nervous system, such as the type and level of injury, the presence of associated injury, timing of surgery, or change in spinal cord neurons and end organs. Several alternative approaches have been proposed to have beneficial effects on peripheral nerve regeneration, including application of an electric field, transplantation of stem cells, and administration of neurotrophic factors. The aim of this work is to study the effect of low intensity electrical stimulation and Mesenchymal stem cells on experimentally induced peripheral nerve injury in Albino rats. 60 albino rats weighing average of 180-250 gm were used in this study. Rats were divided into (5) groups each one contains (12) rats as follows: • Sham surgery group • Injured sciatic nerve control group • Mesenchymal stem cells (MSCs) transplantation group • Electrical stimulation (ES) group • Combined treated group At the end of the experiment in each of the previously mentioned groups sciatic function index, electrophysiological studies, MDA, total antioxidants capacity and BDNF mRNA expression in the sciatic nerve tissue were assessed. Results showed improvement of SFI in ES and MSCs transplantation groups with significantly improved results in the combined treated group after 4 weeks of surgery and reaching almost the same level at the end of experiment. The nerve conduction velocity and MAP results also showed significantly improved values when compared to corresponding values in the injured control group. There was significant reduction in the serum MDA in all treated groups when compared to the injured control group and significantly increased serum total antioxidants capacity in all treated groups when compared to the injured control group. Furthermore the BDNF mRNA level was significantly increased in the all treated groups when compared to the injured control group. Histopathological evaluation showed marked regeneration in the treated groups when compared to the injured control group revealed by restored regular arrangement of the axons and increased thickness and regularity of the nerve, cellularity of schwann cells decrease.