الفهرس 
CHEMISTIY OF PYRIDAZIII·3(2H)·ONES
Reaction with SodamideOnly 14 pages are availabe for public view
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Abstract
This studY inroln:s the smthesis of 6-aryl-..farylmethylpyrida::.
in -312 HJ- ones (128) fi·om the
condensation of Q- methoxy-and 2 . ..f. 6 - trimetho.\T
ben::.aldehyde mth 6-aryl- ..f. 5- dihydropyrida::.m-3 I 2 Hione
s(l2i) under base - cata(ned conditiom 7he reactmry of
the prepared pynda::.inone deri1’ati1’es (128) to1mrds
reagenTs ore sllld!cd
6-Aryl-..f- (aryl methyl! pyrida::.in- 3!JH;- ones (128)
react in the /actamform 1l’ith ethyl bromoacetate in presence
of sodium methoxide to gr1’e the corresponding et!nl ester
derimti1’e( 129)
Treatmem of 6-aryl-..f- lan1 methyl; pynda::.m 3rJH;ones
(128) 11 1th [.oilmg acel!c anhydnde y1elded tht: .\,
JLenl deri1’atn·t:s (130) and not the 0-,1Cet_11 den1’uliws
H01rerer, 6-aryl-..flaryl methyl; pynda::.in- 3r2!-!J- ones
(128) react in the lac tun form mth phosphorus oxychlonde
to give the corresponding 6-ary/-..f-arylmethy/-3-ch/oropyrida::.
ines (131 ). 6- Aryf--1-lary/ methy/i-3-chloroplnda::mes (131) are
easih· hydroh·::ed mth boz/mg acetzc acid to gzw 6-ary/--1-
rarr! methyl! pyrida::m-3(}HJ- ones (128)
The reactm(\ of the prepared 6- aryl--l-imy! met1n1!-3-
chlorop1-rida::mes (131) toll ards nuc!eophz/zc reag..:nts 11 as
o!so Thn \l’.:’re found to r.:act easr/1 \11117
’ .
sodium a::ide 111 dimet1n1 (ormamzde to gzw the
te tru:: ol op1Fida:: 111e dennJiirt’S (132) and nor the
,7::1dop_1nda::in.: d..:rm1rn·es (133)
6-.-4ryl--l-rarylmetln1!-3-ch!orop1nda::ines ( 131) reacr
11 zrh rhirnurea Trl gh·c’ ri-an1-.1ran1mt’Thl/! p_1rUu::m -
3r:H!- rlnoiiC’S (13-t) or rizezr hmromenL (onns (13-t)”
•rlnch >rere also ot>ramed by tht> acti011 of phosphorous
penrasu!plude 111 ret?uxmg .n1ene 011 6-,7n1--l- wn/ merln1!
p1ndu::m- 3r:HJ- ont’S (128)
ri-An1--l-rm.-!mt’Tinl!-3- cholorop1nda::mes (131) reuct
11 llh h_1 dra::mi.’ hydrute ro giE’ rhc· hydro::IntJ dc-ril\ITI\ cs
(135) Thtse hnira::irw (135) react mrh ben::a!dehyde 10 gn·e
the corre spondmg hydra::ollc(136) iiirrhen
6- aryl-4- (aryl methylJ-3-chloropyrida~ine (131)
1ras reacted ll’ith sodamide. the corresponding 3-
aminopyrida~ine derivative (137) li’OS obtained. ( 137) ll’as
also synthesised by the action of triphenylphosphine on the
tetra~olopyrida~ine ( 132) to give 3-triphenyl phosphoranylidene
aminopyrida~ine deri\’ative. which hydrolysed \l’ith
acetic acid to give 3-aminopynda~ine derimtiw (137).
The structure of the products are conjmned on the bas1s of
their elemental ana(vsis and spectral data (JR. CT. and
1Hnmr). FinalZr the effect of the prepared pynda~inones
(128) on the grmrth of different classes of microorganisms
1rere studied