الفهرس 
Introduction and aim of the woOnly 14 pages are availabe for public view
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Abstract
INTRODUCTION
AND
AIM Of THE WORK
Cancer detection is still a great diagnostic and
therapeutic challenge. prognosis is extremely poor, because
the disease is generally recognised at a very advanced
stage and its course is very rapid.
Profound
activities of
metabolic changes are
quite small tumors
associated with the
which would otherwise
remain undetected until! they are large enough to produce
local or systemic manifestations. Detection of such rather
early changes have been employed over the past several
years as indicators for the presence of malignancy.
(Waldmann and Herberman, 1982).
Tumor markers, which are substances that can be related
to the presence or progress of neoplasms, were studied
comprehensively as regards the application of their serum
level in mass screening, differential diagnosis, detection
of micrometastasis and monitoring response to therapy.
Unfortunately, measurement of serum level of different
biomarkers has proved to be neither specific nor sensitive
for detection of cancer, (Buccheri et al., 1987