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العنوان
Preparation, Spectroscopic characterization and Biological Activity of Metal Complexes of New Glucose Hydrazone /
المؤلف
Saad, Lamia Mahrous Mahrous.
هيئة الاعداد
مشرف / لمياء محروس محروس سعد
مشرف / عبده سعد الطبل
مشرف / مشيرة محمد عبد الواحد
مشرف / محمد وهبه
الموضوع
Organic compounds - Synthesis. Chemical reactions.
تاريخ النشر
2014.
عدد الصفحات
164 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Inorganic Chemistry
تاريخ الإجازة
1/10/2014
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

from 164

from 164

Abstract

The master thesis include four main chapter I- Introduction This chapter includes an overview of previous researches for complexes of hydrazone ligands and their application
II- Aim of the work
The work aimed to prepare and characterize new hydrazone
ligand and its metal complexes aiming to study their effects
in the treatment of tumor diseases
III- Experimental
This chapter contains the chemical and instruments used in
Practical part of thesis as follow:
1) Preparation of the hydrazone ligand and its metal complexes.
2) characterization of the ligand and its complexes using:
 Physical techniques such as molar conductance and magnetic
susceptibility
 Elemental analyses (C, H, N, Cl and M).
 Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra
and ESR measurements.
 Thermal techniques as DTA. and TGA
3) Measurement of biological activity
English summary
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iv. Results and discussion
This chapter includes characterization of the ligand and its complexes.
The ligand 4-methyl-N (2,3,4,5,6 pentahydroxyhexaly -diene)
benzohydrazide was prepared as follow:
1- Condensation of glucose with of 4-methylbenzohydrazide (1:1)
for three hours to obtain glucose toluenoyl hydrazone .
The reaction of the ligand glucose toluenoyl hydrazone with Cu(II), Mn(II),
Fe(III), Co(II), Ni(II), Zn(II), Cd(II), Pb(II), Hg(II), Tl(I) and Hg(II) ion gave
metal complexes which had been characterized by elemental analyses, IR,
UV- Vis spectra, mass spectra, 1H-NMR spectra, magnetic moments,
conductances, thermal analyses (DTA and TGA) and ESR measurements.
The IR data show that, the ligand behaves as the ligand behaves as neutral or
monobasic bidentate, monobasic tridentate, or dibasic tetradentate type .
Molar conductances in DMF indicate that, the complexes are non- electrolyte.
ESR spectra of solid Cu(II) complexes show axial or isotropic type d(x2-y2)
with covalent bond character, however, Co(II) and Mn(II) complexes show
isotropic type. Cu(II) complex (2), (3) and (4), Zn(II) complex (22) and
Co(II) complex (23) showed better chemotherapeutic effect against HEPG- 2
liver cell line than the standard drug used.